Endocrine Abstracts

Introduction: Leydig cell hypoplasia (LCH) is a rare autosomal recessive condition that interferes with normal development of male external genitalia in 46,XY individuals. It is mediated by mutations in the luteinizing hormone receptor gene (LHCGR), most frequently located in the coding sequence, resulting in impairment of either LH/CG binding or signal transduction.Case report: We report a 32-year-old female which presented with primary amenorrhea, fema...

Objective: Sexual orientation in males and females is considered to be determined in early life and to be virtually unchangeable in the course of adulthood. In contrast some transsexuals report a change in their sexual orientation most overt following sex reassignment procedures. The reason for this phenomenon is unknown.Methods: We asked 106 transsexual (66 MtF and 40 FtM) patients from our endocrine outpatient clinic to complete a questionnaire, retros...

Objective: To examine whether prolactinoma patients have an altered personality profile.Methods: In this cross-sectional study 84 prolactinoma patients were enrolled. As reference groups, we compared 58 patients with non-functioning pituitary adenomas and secondly 168 age and gender matched healthy control subjects. Personality traits were measured with the standardized Eysenck (EPQ) and Cloninger personality (TPQ) questionnaires.R...

Introduction: Treatment with dopamine agonists in patients with PRL adenomas has been associated with weight loss in short-term studies. However, long-term studies on weight changes are lacking. Taq1A is a restriction fragment length polymorphism considered as a gene marker for the D2DR gene. The presence of at least one A1 allele is linked to reduced brain dopaminergic activity due to reduced receptor binding and lower density of the dopamine two receptor.<p clas...

Introduction: Treatment with dopamine agonists in patients with prolactinomas and Parkinson’s disease is associated with central side effects. Central side effects may depend on a substance’s ability to pass the blood-brain barrier which can be actively controlled by transporter molecules such as the P-glycoprotein encoded by the ABCB1 gene.Aim of the study: To determine whether cabergoline is transported by the P-glycoprotein and whether polym...

Introduction: Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, probably due to both structural and functional properties of the tumour.Design: In a retrospective analysis, we investigated clinical characteristics of pain in 277 patients with pituitary disease (n=81 acromegaly; n=50 Cushing’s disease; n=86 prolactinoma; n=60 non-functioning pituitary adenoma). Specific pa...

Objective: In vitro and in vivo models revealed that the somatotropic system exerts central effects on the central nervous system. The objective of this study was to investigate for the first time whether varying endogenous IGF1 levels are associated with mental health outcomes, namely affective disorders, in humans.Design and methods: We included 6773 subjects from the DETECT study, a representative study on primary care patients in German...